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25302 Liver-Kidney-Microsome-1 Antibodies, IgG

Liver-Kidney-Microsome-1 Antibodies, IgG
Test Code: LKM1
Synonyms/Keywords
LKM, LKM1, Autoimmune hepatitis type 2
Useful For
Useful in the diagnosis of autoimmune hepatitis (AIH).  Type 2 AIH is characterized by the presence of LKM-1 antibodies, in the absence of antinuclear antibody (ANA), smooth muscle antibody, or soluble liver antigen (SLA) antibody.  The major target antigen of LKM-1 antibodies has been identified as cytochrome P450 2D6, a microsomal protein found in the endoplasmic reticulum.  LKM-1 antibodies may be detected in a subset of patients with chronic hepatitis C.  Definitive diagnosis of type 2 AIH should be based on the correlation of all available clinical, biochemical, and liver biopsy information.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Serum Red Top Tube (RTT) ​Serum Separator Tube (SST) 1.0 mL 0.75 mL 0.5 mL
Specimen Stability Information
Specimen Type Temperature Time
​ ​Serum ​ ​ ​Ambient ​8 hours
Refrigerate at 2-8 deg Celsius 2 days
Frozen at -20 deg Celsius ​>2 days
Rejection Criteria

Gross Lipemia

​Gross Hemolysis

​Heat inactivated samples
​Microbially contaminated samples
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield Tuesday, Thursday ​1-2 days ​Enzyme Immunoassay
Test Information
Testing is performed on Tuesday and Thursday.Negative samples will be reported the same day. Positive samples will titered the following day (Wednesday or Friday) by IFA.The magnitude of the reported LKM-1 IgG EIA level cannot be correlated to an endpoint titer.
Reference Range Information
Performing Location Reference Range
​Marshfield ​ ​ ​<= 20.0 Units Negative
​20.1-24.9 Units Equivocal
​>= 25.0 Units Positive
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86376 ​ ​ ​ ​
Synonyms/Keywords
LKM, LKM1, Autoimmune hepatitis type 2
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Serum Red Top Tube (RTT) ​Serum Separator Tube (SST) 1.0 mL 0.75 mL 0.5 mL
Specimen Stability Information
Specimen Type Temperature Time
​ ​Serum ​ ​ ​Ambient ​8 hours
Refrigerate at 2-8 deg Celsius 2 days
Frozen at -20 deg Celsius ​>2 days
Rejection Criteria

Gross Lipemia

​Gross Hemolysis

​Heat inactivated samples
​Microbially contaminated samples
Useful For
Useful in the diagnosis of autoimmune hepatitis (AIH).  Type 2 AIH is characterized by the presence of LKM-1 antibodies, in the absence of antinuclear antibody (ANA), smooth muscle antibody, or soluble liver antigen (SLA) antibody.  The major target antigen of LKM-1 antibodies has been identified as cytochrome P450 2D6, a microsomal protein found in the endoplasmic reticulum.  LKM-1 antibodies may be detected in a subset of patients with chronic hepatitis C.  Definitive diagnosis of type 2 AIH should be based on the correlation of all available clinical, biochemical, and liver biopsy information.
Reference Range Information
Performing Location Reference Range
​Marshfield ​ ​ ​<= 20.0 Units Negative
​20.1-24.9 Units Equivocal
​>= 25.0 Units Positive
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield Tuesday, Thursday ​1-2 days ​Enzyme Immunoassay
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86376 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.