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25374 Buprenorphine, Urine, Confirm Only by LCMS

Buprenorphine, Urine, Confirm Only by LCMS
Test Code: CO-BUP
Synonyms/Keywords
Buprenex, Suboxone, Subutex, Temgesic​
Useful For
Detecting exposure to buprenorphine to monitor compliance in taking prescribed medications or to detect abuse
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Urine ​Sage urine collection container ​Sterile plastic container with no preservatives ​7 mL ​5 mL ​3 mL
Specimen Stability Information
Specimen Type Temperature Time
​Urine ​ ​ ​Refrigerate (Preferred) ​14 days
​Ambient ​14 days
​Frozen ​14 days
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Monday through Friday ​2-4 days ​Beckman AU680 Clinical Chemistry System with Emit Immunoassay and Liquid Chromatography/Time of Flight (LC-MS-QToF) or Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) using Multiple Reaction Monitoring (if needed for confirmation)
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.

​This test is a LCMS confirmation only for Buprenorphone.  It is intended for use only in patients where an initial drug screening test has already been performed at the time of the specimen collection (i.e. Point-of-Care drug screening cup, dipstick, etc...).  The specimen will not be screened by immunoassay in the laboratory; it will only be tested by LCMS. If an initial drug screen has not been performed at the specimen collection site, it is more appropriate to order the "Buprenorphine, Urine" (BUP) test code which includes an initial screen.
This test will detect the presence of buprenorphine and its metabolite norbuprenorphine.

Buprenorphine is a member of the opioid family and is used as an alternative to methadone in the treatment of heroin addiction and as an analgesic for treatment of moderate to severe pain.  Buprenorphine is metabolized to norbuprenorphine.  Measurement of buprenorphine and norbuprenorphine assist the clinician in determining patient compliance with treatment.
Reference Range Information
Performing Location Reference Range
Marshfield ​Negative. Positives are reported with a quantitative LC-MS-QToF or LC-MS/MS result.
Interpretation
​Current Cutoff Levels for Toxicology
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80348 ​ ​1 Buprenorphine Confirmation by LCMS ​
​G0480 ​ ​1 ​Buprenorphine Confirmation by LCMS ​For Medicare/Medicaid
Classification
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.
Synonyms/Keywords
Buprenex, Suboxone, Subutex, Temgesic​
Ordering Applications
Ordering Application Description
​COM ​Buprenorphine Confirm, Urine
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Urine ​Sage urine collection container ​Sterile plastic container with no preservatives ​7 mL ​5 mL ​3 mL
Specimen Stability Information
Specimen Type Temperature Time
​Urine ​ ​ ​Refrigerate (Preferred) ​14 days
​Ambient ​14 days
​Frozen ​14 days
Useful For
Detecting exposure to buprenorphine to monitor compliance in taking prescribed medications or to detect abuse
Reference Range Information
Performing Location Reference Range
Marshfield ​Negative. Positives are reported with a quantitative LC-MS-QToF or LC-MS/MS result.
Interpretation
​Current Cutoff Levels for Toxicology
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Monday through Friday ​2-4 days ​Beckman AU680 Clinical Chemistry System with Emit Immunoassay and Liquid Chromatography/Time of Flight (LC-MS-QToF) or Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) using Multiple Reaction Monitoring (if needed for confirmation)
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80348 ​ ​1 Buprenorphine Confirmation by LCMS ​
​G0480 ​ ​1 ​Buprenorphine Confirmation by LCMS ​For Medicare/Medicaid
Classification
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.
For most current information refer to the Marshfield Laboratory online reference manual.