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25402 Lung Cancer, RET (10q11) Rearrangement, FISH, Tissue (FLRET)

Lung Cancer, RET (10q11) Rearrangement, FISH, Tissue (FLRET)
Test Code: FLRETSO
Synonyms/Keywords
​​RET, Lung carcinoma, Non-small cell lung cancer, NSCLC
Useful For
​Identifying RET gene rearrangements in patients with late-stage, lung adenocarcinomas that are negative for EGFR mutations and ALK rearrangements.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume​​
(no repeat)
​Paraffin Tissue Block ​ ​ ​ ​ ​
Collection Processing Instructions
​Provide a reason for referral with each specimen. The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be compromised or delayed.
Specimen Stability Information
Specimen Type ​​Temperature
​Tissue ​ ​Ambient (preferred)
​Refrigerated
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation​​
​Mayo Medical Laboratories ​Monday through Sunday ​7 days ​FISH
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
Performing Location Reference Range​​
​Mayo Medical Laboratories ​Interpretive Report
Interpretation
​A positive result is detected when the percent of cells with an abnormality exceeds the normal cut-off for the probe set.
 
A positive result suggests rearrangement of the RET locus and a tumor that may be responsive to RET kinase inhibitor therapy. A negative result suggests no rearrangement of the RET gene region at 10q11.
 
Clinical and pathological correlation is recommended.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments​​
88271​ ​ ​2 ​DNA probe, each ​
​88275 ​ ​1 ​​Interphase in situ hybridization, 100-300 cells ​
​88291 ​ ​1 ​Interpretation and report ​
Synonyms/Keywords
​​RET, Lung carcinoma, Non-small cell lung cancer, NSCLC
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume​​
(no repeat)
​Paraffin Tissue Block ​ ​ ​ ​ ​
Collection Processing
​Provide a reason for referral with each specimen. The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be compromised or delayed.
Specimen Stability Information
Specimen Type ​​Temperature
​Tissue ​ ​Ambient (preferred)
​Refrigerated
Useful For
​Identifying RET gene rearrangements in patients with late-stage, lung adenocarcinomas that are negative for EGFR mutations and ALK rearrangements.
Reference Range Information
Performing Location Reference Range​​
​Mayo Medical Laboratories ​Interpretive Report
Interpretation
​A positive result is detected when the percent of cells with an abnormality exceeds the normal cut-off for the probe set.
 
A positive result suggests rearrangement of the RET locus and a tumor that may be responsive to RET kinase inhibitor therapy. A negative result suggests no rearrangement of the RET gene region at 10q11.
 
Clinical and pathological correlation is recommended.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation​​
​Mayo Medical Laboratories ​Monday through Sunday ​7 days ​FISH
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments​​
88271​ ​ ​2 ​DNA probe, each ​
​88275 ​ ​1 ​​Interphase in situ hybridization, 100-300 cells ​
​88291 ​ ​1 ​Interpretation and report ​
For most current information refer to the Marshfield Laboratory online reference manual.