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25507 Protein-Immunotyping (PEP,GAM,IT) and Beta 2 Microglobulin

Protein-Immunotyping (PEP,GAM,IT) and Beta 2 Microglobulin
Test Code: GAMPRIT
Synonyms/Keywords
Gammopathy profile, Monoclonal gammopathy profile, IF-B2 panel, Quantitative immunoglobulins in serum (IgG, IgA and IgM) with serum protein electrophoresis and Beta-2 Microglobulin ​
Test Components
IgG, IgA, IgM, Protein electrophoresis (Total Protein, Albumin, Alpha-1, Alpha-2, Beta and Gamma fractions), and Beta-2 Microglobulin.  Immunotyping may be ordered by interpreter, at an additional charge.​
Useful For
Quantitative immunoglobulins and protein electrophroresis are useful for detecting or monitoring monoclonal gammopathies and immune deficiencies.  In inflammatory disorders such as Rheumatoid Arthritis, Lupus and Crohn's Disease, and in lymphoproliferative disorders such as Multiple Myeloma and Chronic Lymphocytic Leukemia, serum B2 levels are frequently elevated, reflecting an increase rate of synthesis.  Serum B2 levels have also been predictors of longevity in patients with Multiple Myeloma.  Serum B2 levels may also be elevated due to renal insufficiency, and are useful in monitoring patients who have undergone renal transplants.​
Specimen Requirements
 
 
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT)​ ​ 2.0 mL Serum​​1.5 mL Serum​1.0 mL Serum
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​Refrigerate ​14 days
Rejection Criteria
Plasma Samples
​Hemolyzed Samples
Performing Laboratory Information
 
 
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​​Monday through Friday

​6-8 hours

 

If Immunotyping is required, an additional 24 hours is required.

Immunoglobulins – Turbidimetric method / The Binding Site, Optilite analyzer

Protein electrophoresis/Sebia Capillarys 2 Protein System​

Test Information
Includes protein electrophoresis, immunoglobulin quantitation and beta-2 microglobulin quantitation.  Phenotyping of heavy chains and light chains (kappa and lambda) may also be performed by Immunotyping electrophoresis for pathologist/PhD interpretation, and will be charged separately​
Reference Range Information
Performing LocationReference Range
​Marshfield

See table Immunoglobulin Reference Ranges for IgG, IgA and IgM reference ranges.

Total Protein:

0 - 12 months: 4.0-7.8 g/dL

13 months - 9 years: 6.0-8.0 g/dL

10 years - 19 years: 6.4-8.6 g/dL

20 years and older: 6.0 - 8.0 g/dL

Albumin: 3.70-4.90 g/dL

Alpha-1 globulin: 0.20-0.40 g/dL

Alpha-2 globulin: 0.50-0.90 g/dL

Beta globulin: 0.60-1.00 g/dL

Gamma globulin: 0.60-1.40 g/dL

Note: occasionally, due to round off error, the sum of all fractions may not exacly equal the Total protein

Beta-2 Microglobulin: 0.9-2.4 mg/L​

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82784​ ​ 3​ IgG, IgA and IgM​ ​
84165​ ​ ​ Protein electrophoresis​ ​
82232​ ​ ​ Beta-2 Microglobulin​ ​
86334​ ​ ​ Immunotyping (If needed)​ ​
Synonyms/Keywords
Gammopathy profile, Monoclonal gammopathy profile, IF-B2 panel, Quantitative immunoglobulins in serum (IgG, IgA and IgM) with serum protein electrophoresis and Beta-2 Microglobulin ​
Test Components
IgG, IgA, IgM, Protein electrophoresis (Total Protein, Albumin, Alpha-1, Alpha-2, Beta and Gamma fractions), and Beta-2 Microglobulin.  Immunotyping may be ordered by interpreter, at an additional charge.​
Ordering Applications
Ordering Application Description
​Centricity ​Prot.-PEP/GAM/IF/B2M
​Cerner ​Prot.-PEP/GAM/IF/B2M
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
 
 
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT)​ ​ 2.0 mL Serum​​1.5 mL Serum​1.0 mL Serum
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​Refrigerate ​14 days
Rejection Criteria
Plasma Samples
​Hemolyzed Samples
Useful For
Quantitative immunoglobulins and protein electrophroresis are useful for detecting or monitoring monoclonal gammopathies and immune deficiencies.  In inflammatory disorders such as Rheumatoid Arthritis, Lupus and Crohn's Disease, and in lymphoproliferative disorders such as Multiple Myeloma and Chronic Lymphocytic Leukemia, serum B2 levels are frequently elevated, reflecting an increase rate of synthesis.  Serum B2 levels have also been predictors of longevity in patients with Multiple Myeloma.  Serum B2 levels may also be elevated due to renal insufficiency, and are useful in monitoring patients who have undergone renal transplants.​
Test Components
IgG, IgA, IgM, Protein electrophoresis (Total Protein, Albumin, Alpha-1, Alpha-2, Beta and Gamma fractions), and Beta-2 Microglobulin.  Immunotyping may be ordered by interpreter, at an additional charge.​
Reference Range Information
Performing LocationReference Range
​Marshfield

See table Immunoglobulin Reference Ranges for IgG, IgA and IgM reference ranges.

Total Protein:

0 - 12 months: 4.0-7.8 g/dL

13 months - 9 years: 6.0-8.0 g/dL

10 years - 19 years: 6.4-8.6 g/dL

20 years and older: 6.0 - 8.0 g/dL

Albumin: 3.70-4.90 g/dL

Alpha-1 globulin: 0.20-0.40 g/dL

Alpha-2 globulin: 0.50-0.90 g/dL

Beta globulin: 0.60-1.00 g/dL

Gamma globulin: 0.60-1.40 g/dL

Note: occasionally, due to round off error, the sum of all fractions may not exacly equal the Total protein

Beta-2 Microglobulin: 0.9-2.4 mg/L​

For more information visit:
Performing Laboratory Information
 
 
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​​Monday through Friday

​6-8 hours

 

If Immunotyping is required, an additional 24 hours is required.

Immunoglobulins – Turbidimetric method / The Binding Site, Optilite analyzer

Protein electrophoresis/Sebia Capillarys 2 Protein System​

For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82784​ ​ 3​ IgG, IgA and IgM​ ​
84165​ ​ ​ Protein electrophoresis​ ​
82232​ ​ ​ Beta-2 Microglobulin​ ​
86334​ ​ ​ Immunotyping (If needed)​ ​
For most current information refer to the Marshfield Laboratory online reference manual.