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25603 Pyruvic Acid, CSF (PYRC)

Pyruvic Acid, CSF (PYRC)
Test Code: PYRCSO
Synonyms/Keywords
​Pyruvic Acid
Useful For
This​ test is useful for investigating possible disorders of mitochondrial metabolism when used in conjunction with blood lactate collected at the same time to determine the lactate-to-pyruvate ratio.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​CSF ​Fluid Collection Device ​ ​0.6 mL 0.3 mL ​
Collection Processing Instructions
Send specimen from vial #2.
Specimen Stability Information
Specimen Type Temperature Time
​CSF ​ ​ ​Frozen ​7 days
​Ambient 7 days​
​Refrigerate ​7 days
Rejection Criteria
Gross hemolysis
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories ​Monday through Friday ​6-8 hours ​Sigma Enzymatic Spectrophotometry/Shimadze UV-1601
Reference Range Information
Performing Location Reference Range
Mayo Medical Laboratories ​CSF in children (8 days-14 years): 0.03-0.23 mmol/L (Literature Reference Range)
Interpretation
​Cerebrospinal fluid (CSF) L:P ratio may assist in evaluation of patients with neurologic dysfunction and normal blood L: P ratios. Blood and CSF specimens should be collected at the same time.

Limitations:
  • Pyruvic acid levels alone have little clinical utility. Abnormal concentrations of pyruvic acid, and lactate-to-pyruvate (L:P) ratios, are not diagnostic for a particular disorder but must be interpreted in the context of the patient's clinical presentation and other laboratory studies. The determination of pyruvic acid is of diagnostic value when lactic acid is measured and the L:P ratio is established in the same specimen.
  • The L:P ratio is elevated in several, but not all mitochondrial respiratory chain disorders. Determination of lactate, pyruvate, and L: P ratio in cerebrospinal fluid is helpful in directing attention toward a possible mitochondrial disorder in cases with predominantly neurologic dysfunction and normal blood lactate levels.
  • When comparing blood and cerebrospinal fluid (CSF) L:P ratios, blood and CSF specimens should be collected at the same time.
  • Correct specimen collection and handling is crucial to achieve reliable results.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​84210 ​ ​ ​ ​
Synonyms/Keywords
​Pyruvic Acid
Ordering Applications
Ordering Application Description
​Centricity ​Pyruvate-CSF
​Cerner ​Pyruvate-CSF
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​CSF ​Fluid Collection Device ​ ​0.6 mL 0.3 mL ​
Collection Processing
Send specimen from vial #2.
Specimen Stability Information
Specimen Type Temperature Time
​CSF ​ ​ ​Frozen ​7 days
​Ambient 7 days​
​Refrigerate ​7 days
Rejection Criteria
Gross hemolysis
Useful For
This​ test is useful for investigating possible disorders of mitochondrial metabolism when used in conjunction with blood lactate collected at the same time to determine the lactate-to-pyruvate ratio.
Reference Range Information
Performing Location Reference Range
Mayo Medical Laboratories ​CSF in children (8 days-14 years): 0.03-0.23 mmol/L (Literature Reference Range)
Interpretation
​Cerebrospinal fluid (CSF) L:P ratio may assist in evaluation of patients with neurologic dysfunction and normal blood L: P ratios. Blood and CSF specimens should be collected at the same time.

Limitations:
  • Pyruvic acid levels alone have little clinical utility. Abnormal concentrations of pyruvic acid, and lactate-to-pyruvate (L:P) ratios, are not diagnostic for a particular disorder but must be interpreted in the context of the patient's clinical presentation and other laboratory studies. The determination of pyruvic acid is of diagnostic value when lactic acid is measured and the L:P ratio is established in the same specimen.
  • The L:P ratio is elevated in several, but not all mitochondrial respiratory chain disorders. Determination of lactate, pyruvate, and L: P ratio in cerebrospinal fluid is helpful in directing attention toward a possible mitochondrial disorder in cases with predominantly neurologic dysfunction and normal blood lactate levels.
  • When comparing blood and cerebrospinal fluid (CSF) L:P ratios, blood and CSF specimens should be collected at the same time.
  • Correct specimen collection and handling is crucial to achieve reliable results.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories ​Monday through Friday ​6-8 hours ​Sigma Enzymatic Spectrophotometry/Shimadze UV-1601
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​84210 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.