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25624 T-Cell Receptor Gene Rearr, PCR, Varies (TCGRV)

T-Cell Receptor Gene Rearr, PCR, Varies (TCGRV)
Test Code: TCGRVSO
Synonyms/Keywords
​Lymphoma vs Benign Process, Reactive Lymphocytic Process, T-Cell Gene Rearrangement, TCGRV, T Cell Gene Rearrangement, T Cell Clonality
Useful For
Determining whether a T-cell population is polyclonal or monoclonal
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Body Fluid ​Sterile Container ​ ​5 mL ​1 mL ​
​Paraffin-embedded bone marrow aspirate clot ​Paraffin block ​ ​ ​ ​
​Frozen Tissue ​Plastic Container ​ ​100 mg ​50 mg ​
​Paraffin-embedded tissue ​Paraffin block ​ ​ ​ ​
​Spinal fluid ​Sterile Vial ​ ​10 mL ​5 mL ​
​Extracted DNA from blood or bone marrow ​1.5 to 2 mL tube with indication of volume and concentration of DNA ​ ​Entire Specimen ​50 microliter at
20 ng/microliter		 ​
Collection Processing Instructions
Body fluid or spinal fluid specimens must arrive within 96 hours of collection.

If sending body fluid:
1. If the volume is large, pellet cells prior to sending.
2. Send less volume at ambient temperature or as a frozen cell pellet.

Include Hematopathology Patient Information Sheet.
(http://www.mayomedicallaboratories.com/it-mmfiles/hematopathology-request-form.pdf)
Specimen Stability Information
Specimen Type Temperature Time
​Body Fluid ​ ​ ​Room Temperature ​96 hours
​Refrigerate ​96 hours
​Frozen ​96 hours
​Cell Pellet ​Frozen ​96 hours
​Paraffin-embedded bone marrow aspirate clot ​ ​Room Temperature ​Indefinitely
​Refrigerate ​​Indefinitely
​Frozen Tissue ​Frozen ​​Indefinitely
​Parrafin-embedded tissue ​ ​ ​Room Temperature ​​Indefinitely
​Refrigerate ​​Indefinitely
​Frozen ​​Indefinitely
​Spinal Fluid ​ ​Room Temperature ​96 hours
​Refrigerate ​96 hours
​Extracted DNA from blood or bone marrow ​ ​Room Temperature ​​Indefinitely
​Refrigerate ​​Indefinitely
Rejection Criteria
Bone marrow biopsies, slides or paraffin shavings
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Monday through Friday ​7-14 days ​DNA Extracted for Analysis/Polymerase Chain Reaction (PCR)
Test Information

This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the U.S. Food and Drug Administration.  The FDA has determined that such clearance or approval is not necessary.  This test is for clinical purposes.  It should not be regarded as investigational or for research.  This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) as qualified to perform high complexity clinical testing.

​
Reference Range Information
Performing Location Reference Range
​Mayo Medical Laboratories ​Positive, negative, or indeterminate for a clonal T-cell population
Interpretation
An interpretive report will be provided. Results will be characterized as positive, negative, or indeterminate for a clonal T-cell population. In the appropriate clinicopathologic setting, a monoclonal result is associated with a neoplastic proliferation of T cells (see Cautions).
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​81340 ​ ​ ​TCB gene rearrangement, PCR ​
​81342 ​ ​ ​​TCG @ gene rearrangement analysis ​
Classification

This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the U.S. Food and Drug Administration.  The FDA has determined that such clearance or approval is not necessary.  This test is for clinical purposes.  It should not be regarded as investigational or for research.  This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) as qualified to perform high complexity clinical testing.

​
Synonyms/Keywords
​Lymphoma vs Benign Process, Reactive Lymphocytic Process, T-Cell Gene Rearrangement, TCGRV, T Cell Gene Rearrangement, T Cell Clonality
Ordering Applications
Ordering Application Description
​COM ​T-Cell Receptor Rearr, Varies
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Body Fluid ​Sterile Container ​ ​5 mL ​1 mL ​
​Paraffin-embedded bone marrow aspirate clot ​Paraffin block ​ ​ ​ ​
​Frozen Tissue ​Plastic Container ​ ​100 mg ​50 mg ​
​Paraffin-embedded tissue ​Paraffin block ​ ​ ​ ​
​Spinal fluid ​Sterile Vial ​ ​10 mL ​5 mL ​
​Extracted DNA from blood or bone marrow ​1.5 to 2 mL tube with indication of volume and concentration of DNA ​ ​Entire Specimen ​50 microliter at
20 ng/microliter		 ​
Collection Processing
Body fluid or spinal fluid specimens must arrive within 96 hours of collection.

If sending body fluid:
1. If the volume is large, pellet cells prior to sending.
2. Send less volume at ambient temperature or as a frozen cell pellet.

Include Hematopathology Patient Information Sheet.
(http://www.mayomedicallaboratories.com/it-mmfiles/hematopathology-request-form.pdf)
Specimen Stability Information
Specimen Type Temperature Time
​Body Fluid ​ ​ ​Room Temperature ​96 hours
​Refrigerate ​96 hours
​Frozen ​96 hours
​Cell Pellet ​Frozen ​96 hours
​Paraffin-embedded bone marrow aspirate clot ​ ​Room Temperature ​Indefinitely
​Refrigerate ​​Indefinitely
​Frozen Tissue ​Frozen ​​Indefinitely
​Parrafin-embedded tissue ​ ​ ​Room Temperature ​​Indefinitely
​Refrigerate ​​Indefinitely
​Frozen ​​Indefinitely
​Spinal Fluid ​ ​Room Temperature ​96 hours
​Refrigerate ​96 hours
​Extracted DNA from blood or bone marrow ​ ​Room Temperature ​​Indefinitely
​Refrigerate ​​Indefinitely
Rejection Criteria
Bone marrow biopsies, slides or paraffin shavings
Useful For
Determining whether a T-cell population is polyclonal or monoclonal
Reference Range Information
Performing Location Reference Range
​Mayo Medical Laboratories ​Positive, negative, or indeterminate for a clonal T-cell population
Interpretation
An interpretive report will be provided. Results will be characterized as positive, negative, or indeterminate for a clonal T-cell population. In the appropriate clinicopathologic setting, a monoclonal result is associated with a neoplastic proliferation of T cells (see Cautions).
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Monday through Friday ​7-14 days ​DNA Extracted for Analysis/Polymerase Chain Reaction (PCR)
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​81340 ​ ​ ​TCB gene rearrangement, PCR ​
​81342 ​ ​ ​​TCG @ gene rearrangement analysis ​
Classification

This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the U.S. Food and Drug Administration.  The FDA has determined that such clearance or approval is not necessary.  This test is for clinical purposes.  It should not be regarded as investigational or for research.  This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) as qualified to perform high complexity clinical testing.

​
For most current information refer to the Marshfield Laboratory online reference manual.