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25647 NT-Pro-B Type Natriuretic Peptide (PBNP)

NT-Pro-B Type Natriuretic Peptide (PBNP)
Test Code: PBNPSO
Synonyms/Keywords
​N Termial proNP, NT Pro BNP, ProBNP (B-Type Natriuretic Peptide)
Useful For
​An aid in the diagnsis of congestive heart failure.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Serum ​Serum Separator Tube (SST) ​Red Top Tube (RTT) ​0.5 mL ​0.3 mL ​
Collection Processing Instructions
​Serum gel tubes should be centrifuged within 2 hours of collection.  Red Top Tubes should be centrifuged and aliquoted within 2 hours of collection.  Patient's age and sex are required.
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​Frozen (preferred) ​365 days
​ ​Refrigerate ​7 days
Rejection Criteria
Hemolysis-Gross Reject
Interference
​Lack of N-ternimal-pro brain natrurectic peptid (NT-proBNP) elevations have been reported if congestive heart failure is very acute (first honor) or occurs with ventricular inflow obstruction (hypertrophic obstructive cardiomyopathy, mitral stenosis, atrial myxoma).
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Monday through Sunday ​1 day ​Electrochemiluminescence Immunoassay
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
See Report
Interpretation
​
<50 years of age
NT-proBNP values <300 pg/mL have a 99% negative predictive value for excluding acute congestive heart failure (CHF). A cutoff of 1,200 pg/mL for patients with an eGFR <60 yields a diagnostic sensitivity and specificity of 89% and 72% for acute CHF. NT-proBNP values >450 pg/mL are consistent with CHF in adults under 50 years of age.
50-75 years of age
NT-proBNP values <300 pg/mL have a 99% negative predictive value for excluding acute CHF. A cutoff of 1,200 pg/mL for patients with an eGFR <60 yields a diagnostic sensitivity and specificity of 89% and 72% for acute CHF. A diagnostic NT-proBNP cutoff of 900 pg/mL has been suggested in adults 50 to 75 years of age in the absence of renal failure.
>75 years of age
NT-proBNP values <300 pg/mL have a 99% negative predictive value for excluding acute CHF. A cutoff of 1,200 pg/mL for patients with an eGFR <60 yields a diagnostic sensitivity and specificity of 89% and 72% for acute CHF. A diagnostic NT-proBNP cutoff of 1,800 pg/mL has been suggested in adults over 75 years of age in the absence of renal failure.
 
NT-Pro BNP levels are loosely correlated with New York Heart Association (NYHA) functional class (see Table).
 
Interpretive Levels for CHF
Functional Class
5th to 95th Percentile
Median
I
31-1,110 pg/mL
377 pg/mL
II
55-4,975 pg/mL
1,223 pg/mL
III
77-26,916 pg/mL
3,130 pg/mL
IV
*
*
*In a Mayo Clinic study of 75 patients with CHF, only 4 were characterized as Class IV. Accordingly, range and median are not provided.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​83880 ​ ​ ​ ​
Synonyms/Keywords
​N Termial proNP, NT Pro BNP, ProBNP (B-Type Natriuretic Peptide)
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Serum ​Serum Separator Tube (SST) ​Red Top Tube (RTT) ​0.5 mL ​0.3 mL ​
Collection Processing
​Serum gel tubes should be centrifuged within 2 hours of collection.  Red Top Tubes should be centrifuged and aliquoted within 2 hours of collection.  Patient's age and sex are required.
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​Frozen (preferred) ​365 days
​ ​Refrigerate ​7 days
Rejection Criteria
Hemolysis-Gross Reject
Interference
​Lack of N-ternimal-pro brain natrurectic peptid (NT-proBNP) elevations have been reported if congestive heart failure is very acute (first honor) or occurs with ventricular inflow obstruction (hypertrophic obstructive cardiomyopathy, mitral stenosis, atrial myxoma).
Useful For
​An aid in the diagnsis of congestive heart failure.
Reference Range Information
See Report
Interpretation
​
<50 years of age
NT-proBNP values <300 pg/mL have a 99% negative predictive value for excluding acute congestive heart failure (CHF). A cutoff of 1,200 pg/mL for patients with an eGFR <60 yields a diagnostic sensitivity and specificity of 89% and 72% for acute CHF. NT-proBNP values >450 pg/mL are consistent with CHF in adults under 50 years of age.
50-75 years of age
NT-proBNP values <300 pg/mL have a 99% negative predictive value for excluding acute CHF. A cutoff of 1,200 pg/mL for patients with an eGFR <60 yields a diagnostic sensitivity and specificity of 89% and 72% for acute CHF. A diagnostic NT-proBNP cutoff of 900 pg/mL has been suggested in adults 50 to 75 years of age in the absence of renal failure.
>75 years of age
NT-proBNP values <300 pg/mL have a 99% negative predictive value for excluding acute CHF. A cutoff of 1,200 pg/mL for patients with an eGFR <60 yields a diagnostic sensitivity and specificity of 89% and 72% for acute CHF. A diagnostic NT-proBNP cutoff of 1,800 pg/mL has been suggested in adults over 75 years of age in the absence of renal failure.
 
NT-Pro BNP levels are loosely correlated with New York Heart Association (NYHA) functional class (see Table).
 
Interpretive Levels for CHF
Functional Class
5th to 95th Percentile
Median
I
31-1,110 pg/mL
377 pg/mL
II
55-4,975 pg/mL
1,223 pg/mL
III
77-26,916 pg/mL
3,130 pg/mL
IV
*
*
*In a Mayo Clinic study of 75 patients with CHF, only 4 were characterized as Class IV. Accordingly, range and median are not provided.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Monday through Sunday ​1 day ​Electrochemiluminescence Immunoassay
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​83880 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.