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26000 1p19q Deletion in Gliomas, FISH, Tissue (GLIOF)

1p19q Deletion in Gliomas, FISH, Tissue (GLIOF)
Test Code: FGLIOSO
Synonyms/Keywords
p-/19q in Glioma, 1p/19q Deletion Detection, Chromosome Analysis by FISH for 1p/19q Deletion in Gliomas, FISH for 1p/19q Deletion in Gliomas, LOH (Loss of Heterozygosity) 1p/19q in Gliomas, Oligodendroglioma
Useful For
A​s an aid in diagnosing oligodendroglioma tumors and predicting the response of an oligodendroglioma to therapy.
The test may be useful in tumors with a complex "hybrid" morphology requiring differentiation from pure astrocytomas to support the presence of oligodendroglial differentiation/lineage.
 
The test is indicated when a diagnosis of olugodendroglioma, both low-grade World Health Organization ([WHO], grade II) and anaplastic ([WHO], grade III) is redndered.  The test also is strongly recommended in mixed oligoastrocytomas.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​​Formalin fixed Paraffin block and 1 H&E stained slide ​ ​ ​ ​ ​
Specimen Stability Information
Specimen Type Temperature
​Formalin fixed Paraffin block and slides ​Room Temperature
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Daily ​10 days ​FISH using DNA probes
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
See Report
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​88271 ​ 2 ​DNA probe, each ​
​88291 ​ ​1 ​Interpretation and Report ​
​88271 ​ 1 ​Probe, +1 ​if needed
​88271 ​ 2 ​​Probe, +2 ​if needed
​88271 ​ ​3 ​Probe, +3 ​if needed
​88271 ​ ​2 ​Probe set, count ​if needed
​88274 ​ ​1 ​​Interphases, 25-99 ​if needed
​88275 ​ ​1 ​​Interphases, 100-300 ​if needed
88274​ ​ ​1 ​​Interphases, <25 ​​if needed
Synonyms/Keywords
p-/19q in Glioma, 1p/19q Deletion Detection, Chromosome Analysis by FISH for 1p/19q Deletion in Gliomas, FISH for 1p/19q Deletion in Gliomas, LOH (Loss of Heterozygosity) 1p/19q in Gliomas, Oligodendroglioma
Ordering Applications
Ordering Application Description
​All ​1p19q Deletion in Gliomas, FISH, Tissue (GLIOF)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​​Formalin fixed Paraffin block and 1 H&E stained slide ​ ​ ​ ​ ​
Specimen Stability Information
Specimen Type Temperature
​Formalin fixed Paraffin block and slides ​Room Temperature
Useful For
A​s an aid in diagnosing oligodendroglioma tumors and predicting the response of an oligodendroglioma to therapy.
The test may be useful in tumors with a complex "hybrid" morphology requiring differentiation from pure astrocytomas to support the presence of oligodendroglial differentiation/lineage.
 
The test is indicated when a diagnosis of olugodendroglioma, both low-grade World Health Organization ([WHO], grade II) and anaplastic ([WHO], grade III) is redndered.  The test also is strongly recommended in mixed oligoastrocytomas.
Reference Range Information
See Report
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Daily ​10 days ​FISH using DNA probes
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​88271 ​ 2 ​DNA probe, each ​
​88291 ​ ​1 ​Interpretation and Report ​
​88271 ​ 1 ​Probe, +1 ​if needed
​88271 ​ 2 ​​Probe, +2 ​if needed
​88271 ​ ​3 ​Probe, +3 ​if needed
​88271 ​ ​2 ​Probe set, count ​if needed
​88274 ​ ​1 ​​Interphases, 25-99 ​if needed
​88275 ​ ​1 ​​Interphases, 100-300 ​if needed
88274​ ​ ​1 ​​Interphases, <25 ​​if needed
For most current information refer to the Marshfield Laboratory online reference manual.