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26014 Parental Prenatal Array Prep Test (PPAP)

Parental Prenatal Array Prep Test (PPAP)
Test Code: PPAPSO
Useful For
​Preparing parental blood samples for possible confirmation testing if an abnormality is detected on the prenatal array sample.
 
DNA extraction of the maternal blood sample used for maternal cell contamination testing.
 
This test can only be ordered on the parents when a prenatal microarray test has been ordered on the fetal sample.
This test code contains no charge and serves as a way to correlate proband and parental specimens. If additional testing is warranted, the appropriate tests will be added. 
 
When prenatal microarray analysis is ordered, parental blood samples are collected and prepared for confirmation studies should an abnormality be detected on the prenatal sample. If an abnormality is detected on the fetal sample, the most appropriate testing (microarray, FISH, or chromosome analysis) to aid in the interpretation of the prenatal result is performed on the parental samples. A paternal blood sample is desired but not required.
 
Maternal cell contamination testing will be performed on the maternal blood and prenatal samples to rule out the presence of maternal cells in the fetal sample.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ ​Whole Blood ​Green Top Tube Sodium Heparin (GTT) AND Lavendar Top Tube (EDTA) ​

​GTT-4 mL

EDTA-3 mL

 ​ ​
Collection Processing Instructions

​This test requires 2 blood specimens: 1 sodium heparin and 1 EDTA.

1. Invert several times to mix blood.
2. Send specimens in original tubes.

Specimen Stability Information
Specimen Type Temperature
​Whole Blood ​ ​Ambient (preferred)
​Refrigerate
Rejection Criteria
No specimen should be rejected.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Monday through Sunday ​Varies ​The heparinized sample will be cultured following standard laboratory protocols and a fixed-cell pellet will be prepared. DNA will be extracted from the EDTA sample and used to perform maternal cell contamination testing on the maternal sample. The fixed cell pellet and DNA will be stored in the laboratory for possible confirmation testing if an abnormality is detected on the prenatal array sample.(Unpublished Mayo method)
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
Inrterpretive Report
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ ​Whole Blood ​Green Top Tube Sodium Heparin (GTT) AND Lavendar Top Tube (EDTA) ​

​GTT-4 mL

EDTA-3 mL

 ​ ​
Collection Processing

​This test requires 2 blood specimens: 1 sodium heparin and 1 EDTA.

1. Invert several times to mix blood.
2. Send specimens in original tubes.

Specimen Stability Information
Specimen Type Temperature
​Whole Blood ​ ​Ambient (preferred)
​Refrigerate
Rejection Criteria
No specimen should be rejected.
Useful For
​Preparing parental blood samples for possible confirmation testing if an abnormality is detected on the prenatal array sample.
 
DNA extraction of the maternal blood sample used for maternal cell contamination testing.
 
This test can only be ordered on the parents when a prenatal microarray test has been ordered on the fetal sample.
This test code contains no charge and serves as a way to correlate proband and parental specimens. If additional testing is warranted, the appropriate tests will be added. 
 
When prenatal microarray analysis is ordered, parental blood samples are collected and prepared for confirmation studies should an abnormality be detected on the prenatal sample. If an abnormality is detected on the fetal sample, the most appropriate testing (microarray, FISH, or chromosome analysis) to aid in the interpretation of the prenatal result is performed on the parental samples. A paternal blood sample is desired but not required.
 
Maternal cell contamination testing will be performed on the maternal blood and prenatal samples to rule out the presence of maternal cells in the fetal sample.
Reference Range Information
Inrterpretive Report
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Monday through Sunday ​Varies ​The heparinized sample will be cultured following standard laboratory protocols and a fixed-cell pellet will be prepared. DNA will be extracted from the EDTA sample and used to perform maternal cell contamination testing on the maternal sample. The fixed cell pellet and DNA will be stored in the laboratory for possible confirmation testing if an abnormality is detected on the prenatal array sample.(Unpublished Mayo method)
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
For most current information refer to the Marshfield Laboratory online reference manual.