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26020 Vascular Endothelial Growth Factor, Plasma (VEGF)

Vascular Endothelial Growth Factor, Plasma (VEGF)
Test Code: FVEGFSO
Useful For

Evaluation of patients with suspected POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome, particularly in differentiating from other forms of polyneuropathy and monoclonal plasma cell disorders. 

Monitoring response to treatment in patients with a known diagnosis of POEMS syndrome

Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Plasma ​EDTA Lavender Top Tube (LTT) ​ ​0.5 mL ​0.3 mL ​
Collection Processing Instructions
1. Immediately after drawing the specimen, place the tube on wet ice.
2. Spin down and separate plasma from cells; 1,500 x g for 10 minutes at 4 degrees C.
3. Freeze specimen within 30 minutes
Specimen Stability Information
Specimen Type Temperature Time
​Plasma EDTA ​ ​Frozen (preferred) ​21 days
​Refrigerate ​24 hours
Rejection Criteria

Gross hemolysis

Specimens other than EDTA plasma

Interference
​VEGF has limited stability. Following centrifugation, plasma must be either immediately frozen or refrigerated. Samples can only be stored at refrigerated temperatures for 24 hours, after which time samples must be frozen. Storage of plasma for any length of time at room temperature is not acceptable.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Thursday 1 day ​Electrochemiluminescence
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
< or =96.2 pg/mL
Interpretation
​Elevated concentration of vascular endothelial growth factor (VEGF) may be consistent with a diagnosis of POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome.   Decreasing concentrations of VEGF over time in a patient with POEMS syndrome may be consistent with a therapeutic response.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​83520 ​ ​1 ​ ​
Ordering Applications
Ordering Application Description
​COM ​ Endo Growth F (VEGF)
​Centricity ​ Endo Growth F (VEGF)
​Cerner ​ Endo Growth F (VEGF)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Plasma ​EDTA Lavender Top Tube (LTT) ​ ​0.5 mL ​0.3 mL ​
Collection Processing
1. Immediately after drawing the specimen, place the tube on wet ice.
2. Spin down and separate plasma from cells; 1,500 x g for 10 minutes at 4 degrees C.
3. Freeze specimen within 30 minutes
Specimen Stability Information
Specimen Type Temperature Time
​Plasma EDTA ​ ​Frozen (preferred) ​21 days
​Refrigerate ​24 hours
Rejection Criteria

Gross hemolysis

Specimens other than EDTA plasma

Interference
​VEGF has limited stability. Following centrifugation, plasma must be either immediately frozen or refrigerated. Samples can only be stored at refrigerated temperatures for 24 hours, after which time samples must be frozen. Storage of plasma for any length of time at room temperature is not acceptable.
Useful For

Evaluation of patients with suspected POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome, particularly in differentiating from other forms of polyneuropathy and monoclonal plasma cell disorders. 

Monitoring response to treatment in patients with a known diagnosis of POEMS syndrome

Reference Range Information
< or =96.2 pg/mL
Interpretation
​Elevated concentration of vascular endothelial growth factor (VEGF) may be consistent with a diagnosis of POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome.   Decreasing concentrations of VEGF over time in a patient with POEMS syndrome may be consistent with a therapeutic response.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Thursday 1 day ​Electrochemiluminescence
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​83520 ​ ​1 ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.